European journal of pain : EJP
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Hyperbaric oxygen (HBO2 ) therapy can produce analgesia in patients experiencing various conditions of chronic pain. Previously, we reported that naloxone antagonized the acute antinociceptive effect of both brief (11 min) and longer (60 min) HBO2 treatments. This implied a possible role for opioid receptors in the antinociceptive effects of HBO2 . ⋯ These results demonstrated that both μ- and κ-opioid receptors are involved in mediation of the acute antinociceptive response to HBO2 .