The British journal of surgery
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Multicenter Study Controlled Clinical Trial
Bacterial biofilms and capsular contracture in patients with breast implants.
It has been hypothesized that bacterial biofilms on breast implants may cause chronic inflammation leading to capsular contracture. The association between bacterial biofilms of removed implants and capsular contracture was investigated. ⋯ NCT01138891 (http://www.clinicaltrials.gov).
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Sentinel lymph node (SLN) biopsy has replaced axillary lymph node dissection as the routine staging procedure in clinically node-negative breast cancer. False-negative SLN biopsy results in misclassification and may cause undertreatment of the disease. The aim of this study was to investigate whether serial sectioning of SLNs reveals metastases more frequently in patients with false-negative SLNs than in patients with true-negative SLNs. ⋯ SLN serial sectioning contributes to a higher rate of detection of SLN metastasis. The rate of upstaging of the tumour is similar in false- and true-negative groups of patients.
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Randomized Controlled Trial Comparative Study
Randomized clinical trial of subcutaneous versus interfascial bupivacaine for pain control after midline laparotomy.
Although patient-controlled analgesia for pain management after abdominal surgery is common, efforts to find alternative effective methods to control postoperative pain are continuing. The aim of this study was to compare postoperative pain levels following intermittent regional administration of bupivacaine via a catheter placed in the rectus sheath or subcutaneously at abdominal surgery through midline incisions. ⋯ IRCT138810142982N1 (http://www.irct.ir).
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Randomized Controlled Trial
Late effects of a brief psychological intervention in patients with intermittent claudication in a randomized clinical trial.
The authors previously reported the early results of a trial of a brief psychological intervention to increase physical activity in patients with intermittent claudication. After 4 months, participants in the intervention group walked a mean of 1576 more steps per day than control group participants. The present study followed the original participants to determine whether this behaviour change was maintained over 2 years. ⋯ ISRCTN28051878 (http://www.controlled-trials.com).
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Comparative Study
Left hepatic trisectionectomy for advanced perihilar cholangiocarcinoma.
Data on outcomes of left hepatic trisectionectomy (LT) for perihilar cholangiocarcinoma are limited. The aim of this study was to clarify short- and long-term outcomes of LT for perihilar cholangiocarcinoma. ⋯ LT may provide a good outcome for advanced perihilar cholangiocarcinoma.