The British journal of surgery
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Multicenter Study
Prognostic impact of perineural invasion in intrahepatic cholangiocarcinoma: multicentre study.
The aim of this study was to investigate the prognostic impact of perineural invasion (PNI) on tumour recurrence and survival among patients with resected intrahepatic cholangiocarcinoma (ICC). ⋯ PNI is a strong independent predictor of tumour recurrence and long-term survival following resection of ICC with curative intent, even among patients with early-stage disease. The presence of PNI should be assessed routinely.