The British journal of surgery
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Multicenter Study
Prognostic impact of perineural invasion in intrahepatic cholangiocarcinoma: multicentre study.
The aim of this study was to investigate the prognostic impact of perineural invasion (PNI) on tumour recurrence and survival among patients with resected intrahepatic cholangiocarcinoma (ICC). ⋯ PNI is a strong independent predictor of tumour recurrence and long-term survival following resection of ICC with curative intent, even among patients with early-stage disease. The presence of PNI should be assessed routinely.
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Perforated peptic ulcer (PPU) remains a common condition globally with significant morbidity and mortality. Previous work has demonstrated variation in reporting of patient characteristics in PPU studies, making comparison of studies and outcomes difficult. The aim of this study was to standardize the reporting of patient characteristics, by creating a core descriptor set (CDS) of important descriptors that should be consistently reported in PPU research. ⋯ This study defines the core descriptive items for PPU research, which will allow more robust synthesis of studies.
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MRI plays a pivotal role in the staging of early rectal cancer, resulting in allocation of patients to surgery or organ-sparing treatment. In this large population-based retrospective cohort study, MRI substantially understaged pT3 and overstaged pT1 rectal cancer, in addition to unreliable nodal staging. Based on these findings, MRI is not adequate in allocating patients with rectal cancer to organ-sparing treatment.
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The optimal treatment for patients with locally recurrent rectal cancer (LRRC) is controversial. The aim of this study was to investigate different treatment strategies in two leading tertiary referral hospitals in Europe. ⋯ In radiotherapy-naive patients, neoadjuvant full-course chemoradiation confers the best oncological outcome. However, neoadjuvant therapy does not diminish the need for extended radical surgery to increase R0 resection rates.
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The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. ⋯ Patients with early-onset colonic cancer have a high risk of MSI and defined genetic conditions. Those with MSI tumours have more adverse pathology (budding, KRAS/BRAF mutations, and nodal metastases) than older patients with MSI cancers.