The British journal of surgery
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Review Meta Analysis
Systematic review and meta-analysis of sex differences in outcome after intervention for abdominal aortic aneurysm.
The aim of this study was to assess possible differences in mortality between men and women with an abdominal aortic aneurysm (AAA) treated either by elective repair or following aneurysm rupture. ⋯ Women with an AAA had a higher mortality rate following elective open and endovascular repair.
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Review Meta Analysis
Systematic review and meta-analysis of the relationship between hospital volume and outcome for lower limb arterial surgery.
: The aim was to investigate whether a relationship existed between case volume and outcome for lower limb vascular surgical procedures. ⋯ : Higher-volume hospitals were associated with reduced amputation and mortality rates after lower limb vascular surgery. These data were not as conclusive as those for other vascular surgical procedures owing to significant heterogeneity.
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Review Meta Analysis
Meta-analysis of randomized controlled trials on the safety and effectiveness of early versus delayed laparoscopic cholecystectomy for acute cholecystitis.
: In many countries laparoscopic cholecystectomy for acute cholecystitis is mainly performed after the acute episode has settled because of the anticipated increased risk of morbidity and higher conversion rate from laparoscopic to open cholecystectomy. ⋯ : ELC during acute cholecystitis appears safe and shortens the total hospital stay.
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Review Meta Analysis Comparative Study
Systematic review and meta-analysis of enteral nutrition formulations in acute pancreatitis.
Although the benefits of enteral nutrition in acute pancreatitis are well established, the optimal composition of enteral feeding is largely unknown. The aim of the study was to compare the tolerance and safety of enteral nutrition formulations in patients with acute pancreatitis. ⋯ The use of polymeric, compared with (semi)elemental, formulation does not lead to a significantly higher risk of feeding intolerance, infectious complications or death in patients with acute pancreatitis. Neither the supplementation of enteral nutrition with probiotics nor the use of immunonutrition significantly improves the clinical outcomes.
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Review Meta Analysis
Feasibility of randomized controlled trials in liver surgery using surgery-related mortality or morbidity as endpoint.
There is a shortage of randomized controlled trials (RCTs) on which to base guidelines in liver surgery. The feasibility of conducting an adequately powered RCT in liver surgery using the dichotomous endpoints surgery-related mortality or morbidity was examined. ⋯ The feasibility of conducting an adequately powered RCT in liver surgery using outcomes such as mortality or specific complications seems low. Conclusions of underpowered RCTs should be interpreted with caution. A liver surgery-specific composite endpoint may be a useful and clinically relevant solution to pursue.