Critical care : the official journal of the Critical Care Forum
-
Randomized Controlled Trial
Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis.
Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and puncture (CLP)). ⋯ Hypertonic sodium lactate fluid protects against cardiac dysfunction, mesenteric microcirculation alteration, and capillary leakage during sepsis and simultaneously reduces inflammation and enhances ketone bodies.