Critical care : the official journal of the Critical Care Forum
-
Acute kidney injury (AKI) often complicates sepsis and is associated with high morbidity and mortality. In recent years, several important clinical trials have improved our understanding of sepsis-associated AKI (SA-AKI) and impacted clinical care. ⋯ We discuss lessons learned and potential opportunities to improve the design of clinical trials and generate actionable evidence in future research. We specifically discuss the role of enrichment strategies to target populations that are most likely to derive benefit and the importance of patient-centered clinical trial endpoints and appropriate trial designs with the aim to provide guidance in designing future trials.
-
Randomized Controlled Trial
Effect of a self-developed fixation device on preventing endotracheal intubation-related pressure injury: a randomised controlled trial.
To evaluate the effects of our self-developed endotracheal tube fixation device in mechanically ventilated patients. ⋯ The use of the novel device reduced the incidence of EIRPI, especially lip PI. Trial registration Chinese Clinical Trial Registry ChiCTR2300078132. Registered on 29 November 2023.