J Trauma
-
We studied the effect of additional locking screws on fracture strain and stability in tibial intramedullary nailing. ⋯ Nails with additional locking options, by altering strain and motion at the fracture site, may have the clinical potential to affect fracture healing.
-
Clinical Trial
A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury.
The objective of this study was to evaluate whether the neutrophil elastase (NE) inhibitor, sivelestat, improves leukocyte deformability and pulmonary function in patients with acute lung injury (ALI). ⋯ NE concentration and neutrophil rigidity are significantly increased in SIRS patients with ALI. Sivelestat appears to reduce NE concentration and neutrophil stiffness and improve pulmonary oxygenation in patients with ALI.
-
Comparative Study
Acute respiratory distress syndrome secondary to inhalation of chlorine gas in sheep.
Toxic industrial chemicals (TICs) are potential terrorist weapons. Several TICs, such as chlorine, act primarily on the respiratory tract, but knowledge of the pathophysiology and treatment of these injuries is inadequate. This study aims to characterize the acute respiratory distress syndrome (ARDS) caused by chlorine gas (Cl2) inhalation in a large-animal model. ⋯ Cl2 causes severe, dose-related lung injury, with features seen in both smoke inhalation and in ARDS secondary to systemic disease. This model will be used to test new therapeutic modalities.
-
Injury to the spinal accessory nerve causes paralysis of the trapezius muscle, which is a painful and disabling condition. Many injuries are iatrogenic. Diagnosis is often made after a long delay, suggesting that current clinical signs are inadequate. ⋯ We propose that the resisted active external rotation test should be regarded as the key clinical sign for accessory nerve palsy.