J Trauma
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Using a standardized model of uncontrolled hemorrhagic shock induced by massive splenic injury (MSI), we compared bolus infusion of Ringer's lactate (RL) and hypertonic saline (HTS), combined with splenectomy, to continuous infusion of these solutions and splenectomy in rats. ⋯ Continuous infusion of RL combined with splenectomy was followed by significantly less bleeding than bolus infusion of RL and improved survival time compared with untreated animals. Continuous HTS infusion and bolus infusion of HTS with splenectomy resulted in minimal blood loss and improved survival compared with untreated animals. No significant difference in blood loss or survival time was observed between bolus and continuous HTS infusion.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Prevention of venous thromboembolism in the rehabilitation phase after spinal cord injury: prophylaxis with low-dose heparin or enoxaparin.
This prospective, multicenter study compared low-dose unfractionated heparin (UFH) with enoxaparin for prophylaxis against venous thromboembolism (VTE) during the rehabilitation phase after spinal cord injury. ⋯ In this nonrandomized comparison, enoxaparin appeared more effective than heparin in the prevention of thromboembolic complications during rehabilitation after spinal cord injury. Both interventions were safe in this population.
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Comparative Study
The association between occupant restraint systems and risk of injury in frontal motor vehicle collisions.
An evaluation of seat belt use and airbag deployment, either alone or in combination, on risk of injury to specific body regions has yet to be completed. ⋯ Airbag deployment does not appear to significantly reduce the risk of injury either alone or in combination with seat belts. Airbag deployment without associated seat belt use may increase the risk of lower extremity injury.