J Trauma
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Coagulopathy resulting from hydroxyethyl starch (HES) administration is well documented for high-molecular-weight, highly substituted HES solutions. These are the only starch-based synthetic colloids approved for volume replacement in the United States. Recent developments in European colloid solutions revolve around designing new starch molecules. ⋯ This solution is without significant influence on coagulation. Actual experimental work is concentrating on modulating the inflammatory response of monocytes and endothelial cells after infusion of colloid solutions. This may help prevent or even correct capillary leak, and the intravascular persistence of infused colloidal might be prolonged.
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Comparative Study
Multiplicity of solid organ injury: influence on management and outcomes after blunt abdominal trauma.
The current study was undertaken to examine how concomitant injury to liver and spleen after blunt abdominal trauma affects management and outcomes. ⋯ Blunt trauma patients with concomitant injury to liver and spleen have higher Injury Severity Score, mortality, lengths of stay, and transfusion requirements. There is a higher failure rate with nonoperative management, and therefore extra vigilance is warranted when choosing this form of therapy in the presence of injury to both organs.
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Meta Analysis
Efficacy of hypertonic saline dextran fluid resuscitation for patients with hypotension from penetrating trauma.
The purpose of this study was to assess whether the administration of hypertonic saline dextran (HSD) was detrimental when administered to patients who were hypotensive because of penetrating injuries to the torso. The administration of HSD causes an immediate and sustained increase in blood pressure that could contribute to an increase in bleeding in the presence of uncontrolled hemorrhage. We prospectively designed a series of questions to be addressed by a meta-analysis of individual patient data using a computerized data file and case report forms from a multicenter study of HSD. ⋯ For patients with penetrating injuries to the torso that result in hypotension, initial fluid resuscitation with HSD is beneficial in improving survival, especially if surgery is subsequently required.
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Much can be learned from studying the deaths that occur in trauma systems as they have developed. Understanding these deaths and the potential effect of trauma systems on reducing death has major implications for designing clinical trials in fluid resuscitation. The availability of new, exciting information regarding fluid composition and physiologic effects argues for new, better-designed clinical trials. By agreeing on the form of resuscitation trials in the future, we will increase our ability to see clinically significant differences in outcome as we move from animal data to clinical efficacy.