Int J Clin Exp Patho
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Int J Clin Exp Patho · Jan 2015
14-3-3ζ up-regulates hypoxia-inducible factor-1α in hepatocellular carcinoma via activation of PI3K/Akt/NF-кB signal transduction pathway.
14-3-3ζ protein, a member of 14-3-3 family, plays important roles in multiple cellular processes. Our previous study showed that 14-3-3ζ could bind to regulate the expression of hypoxia-inducible factor-1α (HIF-1α), which is induced by hypoxia and a crucial factor for induction of tumor metastasis. Moreover, we also have confirmed the response of 14-3-3ζ to hypoxia in our unpublished data as well. ⋯ Blocking of these pathways using indicated inhibitors revealed that 14-3-3ζ enhanced the production of HIF-1α via the activation of PI3K/Akt/NF-кB pathway, which was identical to hypoxia induced HIF-1α expression. For the first time, our study described the key role of 14-3-3ζ in the HIF-1α production in HCC cells. And the molecule exerted its function on HIF-1α both by directly binding to it and via PI3K/Akt/NF-кB signal transduction pathway.
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Int J Clin Exp Patho · Jan 2015
The potential of plasma miRNAs for diagnosis and risk estimation of colorectal cancer.
Circulating microRNAs (miRNAs) were recognized to be potential non-invasive biomarkers for colorectal cancer (CRC) detection and prediction. Meanwhile, the association of the expression of plasma miRNAs with the risk of CRC patients has rarely been analyzed. Therefore, we conducted this study to evaluate the value of plasma miRNAs for CRC diagnosis and risk estimation. ⋯ High expression of plasma miR-106a increased CRC risk by 1.80 -fold. Plasma miR-106a and miR-20a may as noninvasive biomarkers for detecting the CRC. High expression of miR-106a associated with CRC risk.
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Int J Clin Exp Patho · Jan 2015
Case ReportsPigmented villonodular synovitis of the elbow with rdial, median and ulnar nerve compression.
Pigmented villonodular synovitis (PVNS) is a rare, idiopathic proliferative disorder of the synovium. While, PVNS of elbow is extremely rare. We report an 82-year-old female patient with 20-year-history of gradually increased PVNS in her left elbow. ⋯ After the surgery, the patient gained a functional recovery. Two years after surgery she had a tumor recurrence, but without any symptoms of nerve compression syndromes. We discussed its clinical diagnosis, radiological features, MRI findings, pathophysiology, and treatment.
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Int J Clin Exp Patho · Jan 2015
Case ReportsPleuroparenchymal fibroelastosis associated with aluminosilicate dust: a case report.
Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a recently described rare condition, characterized by pleural and subpleural parenchymal fibrosis, predominantly in the upper lobes. The clinical course of this disease is progressive and prognosis is poor, with little information regarding the etiology of IIPPFE. This report describes an IPPFE patient with convincing evidence of inhalational dust and suggests that dust exposure should be considered as a new causative factor of IPPFE.
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Int J Clin Exp Patho · Jan 2015
Procoagulant role of neutrophil extracellular traps in patients with gastric cancer.
Patients with gastric cancer (GC) commonly exhibit a hypercoagulable state that results in significant morbidity and mortality. Recent studies have shown that neutrophil extracellular traps (NETs) trigger coagulation through an intrinsic pathway and contribute to thrombus initiation and progression. In this study, we aimed to determine the procoagulant activity (PCA) of NETs in patients with GC. ⋯ These results suggest that GC creates a systemic environment that primes neutrophils to release procoagulant NETs. Thus, targeting NETs might improve the coagulopathy of patients with GC.