J Buon
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Preoperative radiotherapy (RT) at high-dose short-course or at conventional fractions for rectal cancer has proven effect in increasing the tumor control. The aim of this study was to test the impact of 2 different preoperative RT schemes on local recurrence, distant metastasis and survival rates and to defi ne the indications for each of them. ⋯ The conventional preoperative RT with 50 Gy proved more effective for advanced rectal cancer (T4 or N2) and for sphincter-saving resections for lower-lying tumors. The short scheme 5 x 5 Gy is appropriate for less advanced tumors (T2-3, N0-1), therefore requiring accurate clinical staging.
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To evaluate the correlation of postmastectomy radiotherapy (PMRT) with local relapse rate, disease-free survival (DFS) and overall survival (OS) in a group of breast cancer (BC) patients at intermediate risk for locoregional relapse (stage I-II with either 1-3 positive axillary nodes, or node-negative grade III BC) treated with radical mastectomy. ⋯ Our results did not show that PMRT significantly influences the incidence of disease relapse, DFS and OS in stage I-II BC patients with intermediate risk for disease relapse. However, it seems that PMRT might influence the occurrence of locoregional recurrence in these patients.
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To determine the efficacy, toxicity and survival of concurrent therapy with vinorelbine and a platinum compound with radiotherapy (RT), followed by consolidation chemotherapy with the same drugs, for locally advanced non small cell lung cancer (NSCLC). ⋯ Preliminary analysis indicates that concurrent vinorelbine and a platinum compound with RT followed by consolidation chemotherapy with the same drugs for advanced stage III NSCLC is well tolerated, has considerable activity and positive impact on survival.
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To evaluate the role of some nuclear medicine approaches such as (99m)Tc-MIBI scan and (131)I whole-body scintigraphy (WBS) in the monitoring of patients with differentiated thyroid cancer (DTC). ⋯ (99m)Tc-MIBI scan has been reported to be a highly sensitive technique for the detection of DTC metastases that have lost the capability to uptake (131)I; the combined (99m)Tc-MIBI scintigraphy and serum Tg estimation appear to be an alternative method of radioiodine imaging in cases with DTC and elevated Tg.