ISA transactions
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This study reports on hearing loss due to the combined effects of noise and sodium salicylate. A group of 10 adult chinchillas was used to test the hypothesis that the combined effects of prolonged exposure to noise and continuous salicylate intoxication will result in a larger Temporary Threshold Shift (TTS) in the audibility curve than either of the agents alone can produce. Extensive behavioral training was used to determine hearing thresholds. ⋯ Serum salicylate levels of 20-40 mg per 100 ml resulted in a TTS of 30 dB on the average. The combination of noise and sodium salicylate exposure produced a temporary hearing loss of approximately 55 dB. These data suggested that the combination of prolonged noise and salicylate exposure may result in a larger hearing loss than either agent alone can produce.