Minerva anestesiologica
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Minerva anestesiologica · Jun 2004
Randomized Controlled Trial Clinical TrialEpidural analgesia in abdominal surgery: 0.2% ropivacaine with sufentanil.
Combining an opioid with peridural local analgesia is an excellent technique to control post-operative pain. Sufentanil is a widely used opioid agent, but its optimal dosage has not yet been defined. In this study we wanted to determine the best dose of epidural sufentanil in major surgery. ⋯ Epidural analgesia is an efficacious and reliable technique. The combination of 0.2% ropivacaine and 0.75 microg/ml(-1) sufentanil was found to be the optimum choice between analgesic efficacy and minor side effects, which correlated with the higher dose of sufentanil given to group C.
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Minerva anestesiologica · Apr 2004
Randomized Controlled Trial Clinical TrialHemofiltration in the prevention of radiocontrast agent induced nephropathy.
The aim of the study was to investigate the role of hemofiltration in preventing contrast nephropathy in patients with renal failure. ⋯ In patients with renal failure undergoing PCI, peri-procedural hemofiltration is effective for the prevention of contrast nephropathy, and is associated with improved in-hospital and long-term outcome.
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Minerva anestesiologica · Mar 2004
Randomized Controlled Trial Comparative Study Clinical TrialPeri-intubation cardiovascular response during low dose remifentanil or sufentanil administration in association with propofol TCI. A double blind comparison.
The aim of this study was to compare the effects on cardiovascular modifications induced by tracheal intubation when low dose infusion of remifentanil or sufentanil are used in association with propofol target controlled infusion. ⋯ In healthy normotensive patients the use of a small dose of either remifentanil or sufentanil after standard midazolam premedication, proved to be an effective strategy to blunt the cardiovascular response to intubation.
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Minerva anestesiologica · Mar 2004
Randomized Controlled Trial Comparative Study Clinical TrialTranexamic acid in primary CABG surgery: high vs low dose.
Prophylactic administration of tranexamic acid decreases bleeding and transfusions after cardiac procedures but it is still unclear what the best dose and the most appropriate timing to get the best results are. ⋯ For elective, first time coronary artery bypass surgery, both dosages of tranexamic acid are equally effective. Theoretically, it seems safer to administer it when patients are protected from thrombus formation by full heparinization.
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Minerva anestesiologica · Jan 2004
Randomized Controlled Trial Comparative Study Clinical TrialAnalgesic transition after remifentanil-based anesthesia in neurosurgery. A comparison of sufentanil and tramadol.
Transition from the end of remifentanil infusion and postoperative analgesia must be planned carefully owing to remifentanil's (R) rapid offset. Intraoperative morphine has been used for the transition to postoperative analgesia following remifentanil-based anesthesia. Sufentanil (S) is a very potent opioid with high micro-receptor affinity, a much wider therapeutic index and a lower fractional receptor occupancy. These pharmacological and dynamics features make sufentanil an interesting alternative to morphine for immediate postoperative analgesia. ⋯ At the emergence much better control of the transition phase in patients treated with sufentanil: smooth recovery with better tolerability of the endotracheal tube; efficacious analgesia along with cardiocirculatory stability.