Minerva anestesiologica
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Minerva anestesiologica · Oct 2016
Randomized Controlled TrialA comparison of three videolaryngoscopes for double-lumen tubes intubation in simulated easy and difficult airways. A randomised trial.
The King Vision™ (KVL) and Airtraq® videolaryngoscopes may reduce the time to double lumen tube (DLT) intubation compared to the GlideScope® and MacIntosh in simulated easy and difficult airways. ⋯ The Airtraq® and non-channeled KVL required more time over the MacIntosh for DLT intubation, as a primary outcome, but the success rates for the 3 videolaryngoscopes were very high.
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Minerva anestesiologica · Oct 2016
Case ReportsWhole-exome sequencing of a family with local anesthetic resistance.
Local anesthetics (LA) work by blocking sodium conductance through voltage-gated sodium channels. Complete local anesthetic resistance is infrequent, and the cause is unknown. Genetic variation in sodium channels is a potential mechanism for local anesthetic resistance. A patient with a history of inadequate loss of sensation following LA administration underwent an ultrasound-guided brachial plexus nerve block with a complete failure of the block. We hypothesized that LA resistance is due to a variant form of voltage-gated sodium channel. ⋯ We identified a genetic variant that is associated with LA resistance in the gene encoding for Nav1.5. We also demonstrate that Nav1.5 is present in human peripheral nerves to support the plausibility that an abnormal form of the Nav1.5 protein could be responsible for the observed local anesthetic resistance.
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Minerva anestesiologica · Oct 2016
Hazards of intubation in the ICU: role of nasal high flow oxygen therapy for preoxygenation and apneic oxygenation to prevent desaturation.
Acute respiratory failure is one the most common motives for intensive care unit admission. Although results from recent studies with high flow nasal oxygen have challenged our current management of these patients, a substantial number of them will require invasive mechanical ventilation and tracheal intubation. Life-threatening hypoxemia is the most frequent complication of these intubations. ⋯ Studies comparing high flow oxygen to noninvasive ventilation are ongoing and will help clarify the indications of each technique. This paper aims to show the evidence on the potential high flow nasal oxygen bears to improve preoxygenation for intubation outside the operating room. A practical algorithm to decide which preoxygenation device to use is proposed.