Minerva anestesiologica
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Minerva anestesiologica · Dec 2022
Effect of norepinephrine on blood volume, cardiac output, and systemic filling pressure in patients undergoing liver transplantation.
Patients with liver cirrhosis develop symptoms comparable to those of patients with sepsis, who have increased total vascular compliance, which may cause blood pooling in the venous pool. No previous studies have evaluated the effect of using norepinephrine on the intravascular blood volume. We investigated the norepinephrine infusion's effect on the mean systemic filling pressure, venous return, and cardiac preload in patients undergoing liver transplantation. ⋯ The norepinephrine infusion at 0.1 µg-1 kg-1 min-1 was associated with an increase in CO in patients with liver cirrhosis undergoing liver transplantation. Norepinephrine's effect on CO was primarily attributable to an increase in venous return due to an increase in mean systemic filling pressure.
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Minerva anestesiologica · Dec 2022
Research progress of goal-directed fluid therapy in prone position surgery.
Goal-directed fluid therapy (GDFT) is currently recognized as a scientific and reasonable method of perioperative capacity management. However, most of the studies on GDFT are carried out in the supine position, while there are few studies on applying GDFT in the prone position. ⋯ Although it is controversial whether the GDFT strategy can improve the clinical outcome of patients undergoing prone position surgery, it is still the mainstream choice of fluid therapy. In the future, we need to explore further the method of predicting the fluid responsiveness of patients in the prone position, improve the GDFT strategy, and guide the perioperative fluid therapy of patients in the prone position.
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Minerva anestesiologica · Dec 2022
Angiotensin II and angiotensin II receptor 2 levels can predict shock and mortality in septic patients.
The aim of this study was to evaluate the place of angiotensin II and its receptors in the prognosis of septic patients. ⋯ In septic patients, angiotensin II, AT-2 and AT-1/AT-2 levels can predict the probability of shock development and mortality.