Minerva anestesiologica
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Minerva Anestesiol
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Minerva anestesiologica · Sep 2023
Impact of immunosuppressive regimen on ICU acquired pneumonia in critically ill COVID-19.
Immunosuppressors (IS) such as Dexamethasone (DXM), Tocilizumab, and high-dose methylprednisolone boli (HDMB), are used in COVID-19-related acute respiratory distress syndrome (ARDS). This study aimed to determine whether COVID-19 ARDS-related combined IS therapy was associated with an increased incidence of ICU-acquired pneumonia (IAP). ⋯ In critically ill COVID-19, HDMB significantly increases the risk of IAP whereas DXM alone, nor in combination with tocilizumab, did not.