Minerva anestesiologica
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Minerva anestesiologica · Dec 2007
Randomized Controlled TrialSubhypnotic doses of midazolam prevent nausea and vomiting during spinal anesthesia for cesarean section.
We aimed to evaluate the efficacy of subhypnotic doses of midazolam and propofol for peripartum nausea and vomiting during regional anesthesia for elective cesarean section in order to prevent emesis in at least 50% of patients. ⋯ A subhypnotic dose of midazolam (1 mg x h(-1)) was as effective as the subhypnotic dose of propofol (1 mg x kg(-1) x h(-1)) for the prevention of nausea and vomiting in parturients undergoing cesarean section under spinal anesthesia.
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Six years ago, a publication in a quite well known scientific medical journal brought hope and a good dose of optimism to sepsis therapy and the critical care community. For the first time, a careful randomized controlled trial in patients with severe sepsis or septic shock seemed to show a clearly beneficial effect of a new drug, i.e. of activated recombinant human protein C. ⋯ However, further evaluation of the results of the trial and new investigations did not confirm entirely the initial optimism. As a consequence, the adequate indications for this expensive drug remain controversial.
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Minerva anestesiologica · Dec 2007
Randomized Controlled TrialThe analgesic efficacy of tramadol in ambulatory gynecological laparoscopic procedures: a randomized controlled trial.
To evaluate the postoperative analgesic efficacy of intravenous tramadol 50 mg administered before anesthetic induction in patients undergoing ambulatory gynecological laparoscopic procedures. ⋯ Intravenous tramadol 50 mg given before anesthetic induction did not reduce pain intensity but was well tolerated. Although tramadol statistically reduced the paracetamol requirement in the first 24 h postoperatively, it did not seem to provide a significant clinical advantage.