The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · Jun 2012
Cost impact of molecular testing for indeterminate thyroid nodule fine-needle aspiration biopsies.
Molecular testing of fine-needle aspiration (FNA) results helps diagnose thyroid cancer, although the additional cost of this adjunct has not been studied. We hypothesized that FNA molecular testing of two indeterminate categories (follicular lesion of undetermined significance and follicular/Hürthle cell neoplasm) can be cost saving. ⋯ Molecular testing of cytologically indeterminate FNA results is cost saving predominantly because of reduction in two-stage thyroidectomy. Appropriate use of emerging molecular testing techniques may thus help optimize patient care, improve resource use, and avoid unnecessary operation.
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J. Clin. Endocrinol. Metab. · Jun 2012
Impact of hyperglycemia on neuropathological alterations during critical illness.
Although preventing excessive hyperglycemia during critical illness may provide clinical neuroprotection, it remains debated whether normoglycemia is without risk for the brain. ⋯ Preventing hyperglycemia with insulin during critical illness reduced neuropathological abnormalities, with microglial activation being the earliest preventable event. Whether these pathological findings associate with neurological outcome remains unknown.