The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · Jun 2018
Randomized Controlled Trial Multicenter StudySemaglutide Added to Basal Insulin in Type 2 Diabetes (SUSTAIN 5): A Randomized, Controlled Trial.
Combination therapy with insulin and glucagon-like peptide-1 receptor agonists (GLP-1RAs) is important for treating type 2 diabetes (T2D). This trial assesses the efficacy and safety of semaglutide, a GLP-1RA, as an add-on to basal insulin. ⋯ Semaglutide, added to basal insulin, significantly reduced HbA1c and body weight in patients with uncontrolled T2D vs placebo.
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J. Clin. Endocrinol. Metab. · Nov 2017
Multicenter StudyStereotactic Radiosurgery for Cushing Disease: Results of an International, Multicenter Study.
Cushing disease (CD) due to adrenocorticotropic hormone-secreting pituitary tumors can be a management challenge. ⋯ SRS for CD is well tolerated and frequently results in control of hypercortisolism. However, recurrences can occur. SRS should be considered for patients with persistent hypercortisolism after pituitary surgery and as a primary treatment in those unfit for surgery. Long-term endocrine follow-up is essential after SRS.
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J. Clin. Endocrinol. Metab. · May 2017
Randomized Controlled Trial Multicenter StudyPreconception Low-Dose Aspirin Restores Diminished Pregnancy and Live Birth Rates in Women With Low-Grade Inflammation: A Secondary Analysis of a Randomized Trial.
Inflammation is linked to causes of infertility. Low-dose aspirin (LDA) may improve reproductive success in women with chronic, low-grade inflammation. ⋯ In women attempting conception with elevated hsCRP and prior pregnancy loss, LDA may increase clinical pregnancy and live birth rates compared with women without inflammation and reduce hsCRP elevation during pregnancy.
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J. Clin. Endocrinol. Metab. · Mar 2017
Randomized Controlled Trial Multicenter StudyPioglitazone and Risk for Bone Fracture: Safety Data From a Randomized Clinical Trial.
Pioglitazone reduces cardiovascular risk in nondiabetic patients after an ischemic stroke or transient ischemic attack (TIA) but is associated with increased risk for bone fracture. ⋯ Fractures affected 8.8% of placebo-treated patients within 5 years after an ischemic stroke or TIA. Pioglitazone increased the absolute fracture risk by 1.6% to 4.9% and the relative risk by 47% to 60%, depending on fracture classification. Our analysis suggests that treatments to improve bone health and prevent falls may help optimize the risk/benefit ratio for pioglitazone.
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J. Clin. Endocrinol. Metab. · Jan 2017
Randomized Controlled Trial Multicenter StudyLow-Dose Aspirin and Sporadic Anovulation in the EAGeR Randomized Trial.
Among women with a single, recent pregnancy loss, daily preconception low-dose aspirin (LDA) increased the live birth rate with no effect on pregnancy loss. Ovulation is a potential mechanism underlying this effect. ⋯ Daily LDA had no effect on anovulation among women with a history of 1 to 2 pregnancy losses. LDA may affect fertility via other pathways, and these warrant further study.