The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · Mar 2014
Multicenter StudyLong-term follow-up in adrenal incidentalomas: an Italian multicenter study.
The long-term consequences of subclinical hypercortisolism (SH) in patients with adrenal incidentalomas (AIs) are unknown. ⋯ SH is associated with the risk of incident CVEs. Besides the clinical follow-up, in patients with an AI >2.4 cm, a long-term biochemical follow-up is also required because of the risk of SH development.
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J. Clin. Endocrinol. Metab. · Mar 2014
Randomized Controlled Trial Multicenter Study Comparative StudyPasireotide versus octreotide in acromegaly: a head-to-head superiority study.
Biochemical control reduces morbidity and increases life expectancy in patients with acromegaly. With current medical therapies, including the gold standard octreotide long-acting-release (LAR), many patients do not achieve biochemical control. ⋯ Pasireotide LAR demonstrated superior efficacy over octreotide LAR and is a viable new treatment option for acromegaly.
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J. Clin. Endocrinol. Metab. · Jan 2014
Randomized Controlled Trial Multicenter StudyDoes vitamin D improve muscle strength in adults? A randomized, double-blind, placebo-controlled trial among ethnic minorities in Norway.
The effect of vitamin D on muscle strength in adults is not established. ⋯ Daily supplementation with 25 or 10 μg vitamin D3 for 16 weeks did not improve muscle strength or power measured by the jump test, handgrip test, or chair-rising test in this population with low baseline vitamin D status.
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J. Clin. Endocrinol. Metab. · Dec 2013
Randomized Controlled Trial Multicenter Study Comparative StudyA randomized trial of vitamin D₃ supplementation in children: dose-response effects on vitamin D metabolites and calcium absorption.
Changes in serum vitamin D metabolites and calcium absorption with varying doses of oral vitamin D₃ in healthy children are unknown. ⋯ Large increases in serum 25(OH)D with vitamin D₃ supplementation did not increase calcium absorption in healthy children living at 2 different latitudes. Supplementation with 400 IU/d was sufficient to maintain wintertime 25(OH)D concentrations in healthy black, but not white, children.
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J. Clin. Endocrinol. Metab. · Dec 2013
Multicenter StudyObservational study of natural history of small sporadic nonfunctioning pancreatic neuroendocrine tumors.
Asymptomatic sporadic nonfunctioning, well-differentiated pancreatic neuroendocrine tumors (NF-PNETs) are increasingly diagnosed, and their management is controversial because of their overall good but heterogeneous prognosis. ⋯ In selected patients, nonoperative management of asymptomatic sporadic NF-PNETs smaller than 2 cm in size is safe. Larger and prospective multicentric studies with long-term follow-up are now needed to validate this wait-and-see policy.