Am J Dent
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Randomized Controlled Trial Comparative Study
Topical lavender oil for the treatment of recurrent aphthous ulceration.
To determine the laboratory and clinical efficacy of lavender oil in the treatment of recurrent aphthous ulceration (RAU). ⋯ Animals treated with lavender oil showed a significant ulcer size reduction, increased rate of mucosal repair, and healing within 3 days of treatment compared to baseline and placebo groups [2-3 days (90%), 4 days (10%)] (P=0.001). The intraperitoneal LD50 value in mice was 6.5 gm/kg; clinical dermal irritation test showed no sign of irritation in the tested products. Lavender oil showed a broad antibacterial activity against all tested strains; it exhibited significant inhibition on tested bacteria where the value of zone of inhibition ranged from 14.5-24 mm vs Streptomycin (25 microg/disc) 12-22 +/- 0.5 mm; MIC was > 6.4-36 mg/ml. RAU patients treated with lavender oil showed a significant reduction in inflammation level, ulcer size, healing time, from 2-4 days [2 days (40%), 3 days (50%), 4 days (10%)], and pain relief mostly from the first dose, compared to baseline and placebo. No side effects were reported.
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Randomized Controlled Trial Comparative Study
Comparison of ropivacaine and lidocaine with epinephrine for infiltration anesthesia in dentistry. A randomized study.
To compare the efficacy of maxillary infiltration anesthesia with 0.5% plain ropivacaine or 2% lidocaine with epinephrine 1:100,000. ⋯ The efficacy of anesthesia of the lateral and central incisors was 100% for both anesthetics. There were small insignificant differences in effectiveness of canine pulp anesthesia. The mean onset time was significantly shorter for ropivacaine--2.2 minutes vs. 5.1 for lidocaine. Ropivacaine also had a significantly longer duration of action--mean time 79.2 minutes. Ropivacaine caused statistically significant increases in blood pressure and heart rate.
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Randomized Controlled Trial Comparative Study
Efficacy of three toothbrushes on established gingivitis and plaque.
To evaluate the efficacy of three toothbrushes [Colgate 3600 Deep Clean (AFT version), the Colgate 3600 Deep Clean (stapled version) and the Oral B Indicator] on the removal of established gingivitis and plaque. ⋯ 109 subjects complied with the protocol and completed the clinical study. For plaque removal, comparisons were made for whole mouth, at the gingival margin and at interproximal sites. The results of the study indicated that all three test toothbrushes provided statistically significantly reductions in pre- to post-brushing plaque index scores of up to 44.0%, 38.6% and 23.6% respectively, after a single toothbrushing. Relative to the Oral B Indicator toothbrush, the Colgate 360 degree Deep Clean toothbrush (AFT version) and Colgate 360 degrees Deep Clean toothbrush (stapled version) provided a statistically significantly greater removal of plaque of up to 107% and 93.0%, respectively, after a single toothbrushing. Also, the group using the Colgate 360 degree Deep Clean toothbrush (AFT version) and the Colgate 360 degree Deep Clean toothbrush (stapled version) exhibited a statistically significantly greater removal of plaque of up to 575% and 400%, respectively, when compared to the Oral B Indicator toothbrush after 4 weeks. The group using the Colgate 3600 Deep Clean toothbrush (AFT version) and the Colgate 3600 Deep Clean toothbrush (stapled version) exhibited statistically significantly greater reductions in gingivitis of up to 23% and 17%, respectively, and greater reductions in gingivitis severity (bleeding sites) of up to 73% and 52% respectively, as compared to the Oral B Indicator toothbrush after 4 weeks. There was no statistically significant difference between the two Colgate 3600 toothbrushes for any parameter and at any comparison time.
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Randomized Controlled Trial Clinical Trial
Pain elicited during intraoral infiltration with buffered lidocaine.
To evaluate the effect of buffered lidocaine with self reporting of pain elicited during maxillary labial and palatal infiltrations of permanent canines. ⋯ Failed to establish a significant reduction in pain scores for either injection site when buffered lidocaine was injected intraorally.