Age and ageing
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Review Meta Analysis
Is sarcopenia associated with depression? A systematic review and meta-analysis of observational studies.
to explore whether sarcopenia is associated with depression. ⋯ sarcopenia was independently associated with depression. The causal relationship between the two clinical conditions requires future validation with cohort studies.
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the diagnosis of cerebral small vessel disease, a leading cause of vascular dementia (VaD), relies solely on neuroimaging studies. Circulating microRNAs (miRNAs) have been proposed as diagnostic biomarkers in various disorders. Our aim was to identify differentially expressed, circulating miRNAs in small vessel VaD which could serve as diagnostic biomarkers for this disease. ⋯ plasma miR-409-3p, miR-502-3p, miR-486-5p and miR-451a could be used to differentiate small vessel VaD patients from healthy controls. Large-scale studies of their biomarker potential are warranted.