European journal of obstetrics, gynecology, and reproductive biology
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Eur. J. Obstet. Gynecol. Reprod. Biol. · Oct 2001
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialTreatment of preterm labor with the oxytocin antagonist atosiban: a double-blind, randomized, controlled comparison with salbutamol.
To compare the efficacy and safety of atosiban and salbutamol in the treatment of preterm labor. ⋯ The oxytocin antagonist atosiban was found to be better tolerated by both mother and fetus than salbutamol, with a comparable neonatal and infant safety profile, and atosiban was as effective as salbutamol in delaying threatened preterm birth. This study supports the clinical use of atosiban in the treatment of preterm labor.
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Eur. J. Obstet. Gynecol. Reprod. Biol. · Feb 2000
Randomized Controlled Trial Clinical TrialDiclofenac in the treatment of pain after caesarean delivery. An opioid-saving strategy.
Pain relief of good quality after caesarean section (CS) results in early mobilization and good early mother-child interaction. Patient-controlled analgesia (PCA), with systemic opioids, gives a very high level of patient satisfaction. However, opioids have well documented side-effects i.e. sedation, nausea and respiratory depression. To minimize the risk of such negative effects we studied how far the required dose of opioid could be decreased with a multimodal strategy adding diclofenac. ⋯ A multimodal analgetic strategy with the addition of 150 mg diclofenac during the first 24 h after CS reduces the need for opioids significantly with maintained or improved analgetic effect. This is expected to reduce the risk of negative side-effects of systemic opioids.
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Eur. J. Obstet. Gynecol. Reprod. Biol. · Jan 1997
Randomized Controlled Trial Clinical TrialPost-partum urinary retention: a comparison between two methods of epidural analgesia.
To compare two methods of epidural labor analgesia regarding the incidence of post-partum urinary retention. ⋯ EDA significantly increased the risk of post-partum urinary retention but no difference was found between the two epidural techniques.
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Eur. J. Obstet. Gynecol. Reprod. Biol. · Nov 1996
Randomized Controlled Trial Comparative Study Clinical TrialSecond trimester pregnancy termination including fetal death: comparison of five different methods.
To compare the efficacy of methods for second trimester pregnancy termination. ⋯ In comparison with the five methods, the use of extraamniotic ethacridine, intravenous concentrated oxytocin, and balloon was found to provide more effective treatment than intracervical PGE2 and misoprostol in terms of achievement of abortion within 24 and 48 h.
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Eur. J. Obstet. Gynecol. Reprod. Biol. · Aug 1996
Randomized Controlled Trial Comparative Study Clinical TrialS-adenosylmethionine versus ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: preliminary results of a controlled trial.
To evaluate the efficacy of S-adenosylmethionine (SAMe) and ursodeoxycholic acid (UDCA) in intrahepatic cholestasis of pregnancy (ICP). ⋯ These findings show that UDCA is more effective than SAMe in controlling pruritus and total bile acids, which are considered a prognostic parameter in ICP with respect to the fetus. Nevertheless, before UDCA is introduced as an effective and safe treatment for ICP, which also has a beneficial effect on fetal prognosis, we believe these results should be confirmed and extended in other clinical trials.