European journal of obstetrics, gynecology, and reproductive biology
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Eur. J. Obstet. Gynecol. Reprod. Biol. · Apr 2008
Randomized Controlled TrialIntravenous tranexamic acid use in myomectomy: a prospective randomized double-blind placebo controlled study.
To define the effect of tranexamic acid use on perioperative and postoperative bleeding and blood transfusion requirements in women undergoing myomectomy. ⋯ Our study is the first in the literature evaluating the effectiveness of tranexamic acid use on peri- and postoperative bleeding in gynecological surgery. No additional benefit of intravenous infusion of tranexamic acid was found. Tranexamic acid does not seem to be a useful adjunct in myomectomy if given according to the described protocol in this study.
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Eur. J. Obstet. Gynecol. Reprod. Biol. · Feb 2008
Randomized Controlled TrialPreoperative analgesia with local lidocaine infiltration for abdominal hysterectomy pain management.
To evaluate the impact of preemptive local analgesia at the incision site in reducing pain in women undergoing abdominal hysterectomy for a benign myomatous uterus. ⋯ Preemptive analgesia with lidocaine 1% is a simple, cheap and efficient mode to reduce pain in the first hours after hysterectomy.
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Eur. J. Obstet. Gynecol. Reprod. Biol. · Feb 2007
Randomized Controlled TrialSpecialist nurse supported discharge in gynaecology: a randomised comparison and economic evaluation.
To determine the effect on quality of life and cost effectiveness of specialist nurse early supported discharge for women undergoing major abdominal and/or pelvic surgery for benign gynaecological disease compared with routine care. ⋯ Women undergoing major abdominal and pelvic surgery were discharged home earlier with provision of support from a specialist gynaecology nurse. The results of this study suggest that duration of hospital stay can be shortened by the introduction of a specialist nurse without introducing any adverse physical and psychological effects. This process of care is associated with receipt of information on health and lifestyle issues and maintenance of high levels of patient satisfaction and demonstrates the effectiveness of the specialist nurse role in the provision of health information for women. Earlier hospital discharge at 48 h after major abdominal and pelvic surgery is an acceptable, cost effective alternative to current routine practice in the absence of further randomised evidence.
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Eur. J. Obstet. Gynecol. Reprod. Biol. · Dec 2006
Randomized Controlled Trial Comparative StudyInduction of labor with misoprostol in pregnancies with advanced maternal age.
The objective was to compare the efficacy and complications of intravaginal misoprostol application with oxytocin infusion for induction of labor in advanced aged pregnancies with a Bishop score of < 6. ⋯ Intravaginal misoprostol seems to be an alternative method to oxytocin in the induction of labor in advanced aged pregnant women with low Bishop scores, as it is efficacious, cheap, and easy to use. But large studies are necessary to clarify safety with regard to the rare complications such as uterine rupture.
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Eur. J. Obstet. Gynecol. Reprod. Biol. · Sep 2006
Randomized Controlled TrialSevere hypertension in pregnancy: hydralazine or labetalol. A randomized clinical trial.
The objective was to compare the safety and efficacy of intravenous labetalol and intravenous hydralazine for acutely lowering blood pressure in pregnancy. ⋯ This randomized clinical trial shows that labetalol and hydralazine fulfill the criteria required for an antihypertensive drug to treat severe hypertension in pregnancy.