Arch Gen Psychiat
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Meta Analysis Comparative Study
Suicidality in pediatric patients treated with antidepressant drugs.
There has been concern that widely used antidepressant agents might be associated with an increased risk of suicidal ideation and behavior (suicidality) in pediatric patients. ⋯ Use of antidepressant drugs in pediatric patients is associated with a modestly increased risk of suicidality.
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Comparative Study
Adverse events during medical and surgical hospitalizations for persons with schizophrenia.
Persons with schizophrenia have a high risk of premature mortality. It is not clear if greater risk for adverse events during hospitalization is a contributing factor. ⋯ Medical and surgical hospitalizations for persons with schizophrenia had at least twice the odds of several types of adverse events than those for persons without schizophrenia. These adverse events were associated with poor clinical and economic outcomes during the hospital admission. Efforts to reduce these adverse events should become a research priority.
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Multicenter Study Comparative Study
Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study.
Depressive symptoms are common in patients with dementia and may be associated with increased risk of developing dementia. It has been hypothesized that depressive symptoms and dementia may be attributable to underlying vascular disease in some older persons. ⋯ Depressive symptoms were associated with increased risk of MCI, and this association was independent of underlying vascular disease.
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Comparative Study
Depressive symptoms and cognitive decline in late life: a prospective epidemiological study.
Depression is associated with cognitive impairment and dementia. It is less clear whether depression contributes to further cognitive decline over time, independently of incipient dementia. ⋯ Depressive symptoms are cross-sectionally associated with cognitive impairment but not subsequent cognitive decline. Substantial cognitive decline over time cannot be explained by depression and most likely reflects incipient dementia.
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Comparative Study Historical Article
Physical and mental health costs of traumatic war experiences among Civil War veterans.
Hundreds of thousands of soldiers face exposure to combat during wars across the globe. The health effects of traumatic war experiences have not been adequately assessed across the lifetime of these veterans. ⋯ Greater exposure to death of military comrades and younger exposure to war trauma were associated with increased signs of physician-diagnosed cardiac, gastrointestinal, and nervous disease and more unique disease ailments across the life of Civil War veterans. Physiological mechanisms by which trauma might result in disease are discussed.