The Journal of thoracic and cardiovascular surgery
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J. Thorac. Cardiovasc. Surg. · Nov 2003
Comparative StudyThe antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest.
Oxidative stress contributes to myocardial ischemia-reperfusion injury. We hypothesized that administration of the antioxidant N-acetylcysteine would have beneficial effects on myocardial function after cardiopulmonary bypass and cardioplegic arrest. ⋯ Administration of the antioxidant N-acetylcysteine preserves systolic function and enhances myocardial edema resolution after cardiopulmonary bypass/cardioplegic arrest. Furthermore, oxidative stress was significantly reduced in the treated animals. Therefore, our findings support the hypothesis that oxidative stress is the main cause for myocardial dysfunction after ischemia-reperfusion.
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J. Thorac. Cardiovasc. Surg. · Nov 2003
Comment Letter Case ReportsAtrioesophageal fistula: is it an unavoidable complication of radiofrequency ablation?
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J. Thorac. Cardiovasc. Surg. · Nov 2003
Editorial Comment Comparative StudyRight ventricular-pulmonary artery connection in stage 1 palliation of hypoplastic left heart syndrome.