The Journal of thoracic and cardiovascular surgery
-
J. Thorac. Cardiovasc. Surg. · Feb 2019
Recipient hypertonic saline infusion prevents cardiac allograft dysfunction.
Hypertonic saline (HTS) has potent immune and vascular effects. We assessed recipient pretreatment with HTS on allograft function in a porcine model of heart transplantation and hypothesized that HTS infusion would limit endothelial and left ventricular (LV) dysfunction following transplantation. ⋯ Recipient HTS pretreatment preserves allograft vasomotor and LV function, and HTS therapy limits CPB-induced injury. HTS may be a novel recipient intervention to prevent graft dysfunction.
-
J. Thorac. Cardiovasc. Surg. · Feb 2019
Editorial CommentGenes, aortic diseases, and cardiovascular surgery.