The Journal of thoracic and cardiovascular surgery
The most recent articles from:
J. Thorac. Cardiovasc. Surg.
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J. Thorac. Cardiovasc. Surg. · Jul 2023
Adeno-associated virus mediates gene transduction after static cold storage treatment in rodent lung transplantation.
Adeno-associated virus is a clinically used gene therapy vector but has not been studied in lung transplantation. We sought to determine the efficacy of adeno-associated virus delivery during static cold storage via the airway versus the pulmonary artery before lung transplantation in a rodent model. ⋯ Adeno-associated virus mediates gene transduction during static cold storage in rat lung isografts when administered via the airway and pulmonary artery. Airway administration leads to robust transgene expression in respiratory epithelial cells, whereas pulmonary artery administration targets alternative cell types and increases extrapulmonary transgene expression.