The Journal of thoracic and cardiovascular surgery
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Primary sarcomas of the mediastinum are rare, and data concerning treatment and results of therapy are sparse. ⋯ Because the overall survival for patients with mediastinal sarcomas is 32% and the local recurrence is 64% for tumors completely resected, aggressive adjuvant therapy should continue to be systematically explored.
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J. Thorac. Cardiovasc. Surg. · Mar 1998
Sodium/hydrogen exchanger inhibition reduces myocardial reperfusion edema after normothermic cardioplegia.
The hypothesis was that Na+/H+ exchange occurring during normothermic cardioplegia contributes to the development of myocardial edema during subsequent reperfusion and impairs functional recovery. ⋯ Inhibition of the Na+/H+ exchange during normothermic cardioplegia reduces myocardial edema and necrosis during subsequent reperfusion, improving functional recovery. Inhibition of Na+/H+ exchange during reperfusion only has a much smaller effect.
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J. Thorac. Cardiovasc. Surg. · Mar 1998
Simultaneous antegrade and retrograde delivery of continuous warm blood cardioplegia after global ischemia.
Simultaneous delivery of antegrade and retrograde cardioplegia may provide a more homogeneous distribution of cardioplegic solution. It may, however, increase myocardial edema and postcardioplegic myocardial injury. The purpose of this study was to compare simultaneous antegrade-retrograde cardioplegia with antegrade cardioplegia. ⋯ Despite a small increase in myocardial water content induced by simultaneous blood cardioplegia, no impairment of postcardioplegic cardiac function was observed compared with antegrade cardioplegia.
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J. Thorac. Cardiovasc. Surg. · Feb 1998
Randomized Controlled Trial Clinical TrialModified ultrafiltration improves left ventricular systolic function in infants after cardiopulmonary bypass.
Our objective was to test the hypothesis that use of modified ultrafiltration after cardiopulmonary bypass improves intrinsic left ventricular systolic function in children. ⋯ Use of modified ultrafiltration after cardiopulmonary bypass improves intrinsic left ventricular systolic function, improves diastolic compliance, increases blood pressure, and decreases inotropic drug use in the early postoperative period.
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J. Thorac. Cardiovasc. Surg. · Feb 1998
Randomized Controlled Trial Clinical TrialRetrograde autologous priming for cardiopulmonary bypass: a safe and effective means of decreasing hemodilution and transfusion requirements.
The obligatory hemodilution resulting from crystalloid priming of the cardiopulmonary bypass circuit represents a major risk factor for blood transfusion in cardiac operations. We therefore examined whether retrograde autologous priming of the bypass circuit would result in decreased hemodilution and red cell transfusion. ⋯ These data suggest that retrograde autologous priming is a safe and effective means of significantly decreasing hemodilution and the number of patients requiring red cell transfusion during cardiac operations.