Plos One
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Meta Analysis
A meta-analysis of core stability exercise versus general exercise for chronic low back pain.
To review the effects of core stability exercise or general exercise for patients with chronic low back pain (LBP). ⋯ http://www.crd.york.ac.uk/PROSPERO PROSPERO registration number: CRD42011001717.
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The risk of malignancies on TNF-α antagonists is controversial. The aim of this survey was to assess cancer risk on TNF-α antagonists in adult rheumatoid arthritis patients, including the five marketed drugs (infliximab, etanercept, adalimumab, golimumab and certolizumab) used in line with the New Drug Application. Furthermore, the relative interest of modified intention to treat or per protocol analyses to assess such sparse events remains unknown. ⋯ This study did not find any evidence for an excess cancer risk on TNF-α antagonists in adult rheumatoid arthritis patients, but an excess cancer risk after several years of exposure cannot be ruled out. Both modified intention to treat and per protocol analyses should be presented in such safety analyses.