Plos One
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Multicenter Study
Subject-specific increases in serum S-100B distinguish sports-related concussion from sports-related exertion.
The on-field diagnosis of sports-related concussion (SRC) is complicated by the lack of an accurate and objective marker of brain injury. ⋯ Relative and absolute increases in serum S100B can accurately distinguish SRC from sports-related exertion, and may be a useful adjunct to the diagnosis of SRC.
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Meta Analysis
Lower intensified target LDL-c level of statin therapy results in a higher risk of incident diabetes: a meta-analysis.
A recent meta-analysis has reported that intensive-dose statin drug increases the risk of incident diabetes. However, doubling of the statin dose generates only a further 6% decrease in low-density lipoprotein cholesterol (LDL-c) on average. This study aimed to determine whether statin therapy with lower intensive-target LDL-c level contributes to higher risk of new-onset diabetes. ⋯ A lower intensified target LDL-c level of statin therapy resulted in a higher risk of incident diabetes.
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While more and more open procedures now routinely performed using laparoscopy, minimally invasive pancreaticoduodenectomy (MIPD) remains one of the most challenging abdominal procedures. Therefore, we carried out this meta-analysis to evaluate whether MIPD is safe, feasible and worthwhile. ⋯ Our results suggest that MIPD is currently safe, feasible and worthwhile. But considering the selection bias, complexity of MIPD and lack of long-term oncologic outcomes, we suggest it be performed in a high-volume pancreatic surgery center in selected patients.
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The potential benefits of corticosteroids for septic shock may depend on initial mortality risk. ⋯ Risk stratified analysis failed to demonstrate any benefit from corticosteroids in this pediatric septic shock cohort.
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Randomized Controlled Trial
Effectiveness of a training course for general practice nurses in motivation support in type 2 diabetes care: a cluster-randomised trial.
Type 2 diabetes is a common metabolic disease with the potential for prevention of complications. The prevention requires a high level of lasting actions from the patients, which may be burdensome. The aim of this trial was to evaluate the effectiveness of a training course for general practice nurses in motivation support at 18 months follow-up in the affiliated type 2 diabetes population. ⋯ Offering a training course for general practice nurses in applying the Self-determination theory in current type 2 diabetes care had no effect compared with usual practice measured by HbA1c and total cholesterol levels and the well-being at 18 months of follow-up in a comprehensive register-based diabetes population. Subgroup analyses suggested a possible effect in women, which deserves further attention.