Plos One
-
Prioritizing zoonotic diseases is one of the emerging tasks for developing multi-sectoral collaboration within One Health. Globally, many efforts have been made to prioritize zoonotic diseases at national levels, especially in low resource settings. Prioritization of zoonoses has been conducted in different countries at different levels (i.e. national, regional and local) for different purposes. India has also initiated prioritization of zoonotic diseases at the national level. However, in a country like India with wide climatic variations, different animal-human and vector densities, it is important to look at these zoonotic conditions in local settings too. The present study aims to determine which zoonoses should be prioritized for collaboration between stakeholders in the Indian city of Ahmedabad. ⋯ Prioritization of zoonotic diseases at the local level is essential for development of effective One Health strategies. This type of participatory disease prioritization workshop is highly recommended and can be replicated in other Indian cities, as well as in other low and middle-income countries.
-
Multicenter Study
Choice of the initial antiretroviral treatment for HIV-positive individuals in the era of integrase inhibitors.
We aimed to describe the most frequently prescribed initial antiretroviral therapy (ART) regimens in recent years in HIV-positive persons in the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) and to investigate factors associated with the choice of each regimen. ⋯ The choice of initial ART regimens is consistent with Spanish guidelines' recommendations, but is also clearly influenced by physician's perception based on patient's clinical and sociodemographic variables and by the prescribing hospital location.
-
Spatiotemporal patterns of play can be extracted from competitive environments to design representative training tasks and underlying processes that sustain performance outcomes. To support this statement, the aims of this study were: (i) describe the collective behavioural patterns that relies upon the use of player positioning in interaction with teammates, opponents and ball positioning; (ii) and define the underlying structure among the variables through application of a factorial analysis. The sample comprised a total of 1,413 ball possession sequences, obtained from twelve elite football matches from one team (the team ended the season in the top-5 position). ⋯ The EPS of the team in possession was well correlated with the game space, especially the game width facing TOP opponents. Against BOTTOM opponents, there was a strong association of ball possession duration, game width, distance covered by the ball, and length/width ratio of the ball movement. The overall approach carried out in this study may serve as the starting point to elaborate normative models of positioning behaviours measures to support the coaches' operating decisions.
-
Beta-blockers can reduce recurrence, metastasis, and mortality in various cancers. In this study, we investigated the effect of propranolol, a non-selective beta-blocker on overall survival (OS) in unresectable/metastatic hepatocellular carcinoma (HCC) and on recurrence-free survival (RFS) in resectable, curable HCC. ⋯ This study revealed that propranolol could improve OS in unresectable/metastatic HCC.
-
Oxytocin is involved in the regulation of social behaviors including parental behaviors in a variety of species. Oxytocin triggers social behaviors by binding to oxytocin receptors (OXTRs) in various parts of the brain. OXTRs are present in the preoptic area (POA) where hormone-sensitive sexually dimorphic nuclei exist. ⋯ Moreover, ovariectomy resulted in the absence of OXTR-Venus expression in the AVPV, whereas estrogen replacement therapy restored OXTR-Venus expression. These results demonstrate that the expression of OXTR in the AVPV is primarily female specific and estrogen dependent. The presence of the sexually dimorphic expression of OXTR in the AVPV suggests the involvement of OXTR neurons in the AVPV in the regulation of female-specific behavior and/or physiology.