Plos One
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Multicenter Study
Thrombocytopenia is associated with acute respiratory distress syndrome mortality: an international study.
Early detection of the Acute Respiratory Distress Syndrome (ARDS) has the potential to improve the prognosis of critically ill patients admitted to the intensive care unit (ICU). However, no reliable biomarkers are currently available for accurate early detection of ARDS in patients with predisposing conditions. ⋯ This study of ICU patients in both China and US showed that thrombocytopenia is associated with an increased risk of ARDS and platelet count in combination with ARDS had a high predictive value for patient mortality.
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Randomized Controlled Trial Multicenter Study
Atomoxetine effects on executive function as measured by the BRIEF--a in young adults with ADHD: a randomized, double-blind, placebo-controlled study.
To evaluate the effect of atomoxetine treatment on executive functions in young adults with attention-deficit/hyperactivity disorder (ADHD). ⋯ Statistically significantly greater improvement in executive function was observed in young adults with ADHD in the atomoxetine versus placebo group as measured by changes in the BRIEF-A scales.
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Multicenter Study
Subject-specific increases in serum S-100B distinguish sports-related concussion from sports-related exertion.
The on-field diagnosis of sports-related concussion (SRC) is complicated by the lack of an accurate and objective marker of brain injury. ⋯ Relative and absolute increases in serum S100B can accurately distinguish SRC from sports-related exertion, and may be a useful adjunct to the diagnosis of SRC.
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The potential benefits of corticosteroids for septic shock may depend on initial mortality risk. ⋯ Risk stratified analysis failed to demonstrate any benefit from corticosteroids in this pediatric septic shock cohort.
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Multicenter Study
DWI intensity values predict FLAIR lesions in acute ischemic stroke.
In acute stroke, the DWI-FLAIR mismatch allows for the allocation of patients to the thrombolysis window (<4.5 hours). FLAIR-lesions, however, may be challenging to assess. In comparison, DWI may be a useful bio-marker owing to high lesion contrast. We investigated the performance of a relative DWI signal intensity (rSI) threshold to predict the presence of FLAIR-lesions in acute stroke and analyzed its association with time-from-stroke-onset. ⋯ An easily assessable DWI-rSI threshold identifies the presence of lesions in FLAIR-imaging with good accuracy and is associated with time-from-stroke-onset in acute stroke. This finding underlines the potential of a DWI-rSI threshold as a marker of lesion age.