Pediatrics
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Randomized Controlled Trial Multicenter Study
Reducing Antibiotic Prescribing in Primary Care for Respiratory Illness.
One-third of outpatient antibiotic prescriptions for pediatric acute respiratory tract infections (ARTIs) are inappropriate. We evaluated a distance learning program's effectiveness for reducing outpatient antibiotic prescribing for ARTI visits. ⋯ This program reduced antibiotic prescribing during outpatient ARTI visits; broader dissemination may be beneficial.
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Historically, autosomal recessive 5q-linked spinal muscular atrophy (SMA) has been the leading inherited cause of infant death. SMA is caused by the absence of the SMN1 gene, and SMN1 gene replacement therapy, onasemnogene abeparvovec-xioi, was Food and Drug Administration approved in May 2019. Approval included all children with SMA age <2 years without end-stage weakness. However, gene transfer with onasemnogene abeparvovec-xioi has been only studied in children age ≤8 months. ⋯ In this population, with thorough screening and careful post-gene transfer management, replacement therapy with onasemnogene abeparvovec-xioi is safe and shows promise for early efficacy.
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Biography Historical Article
The Death of George Floyd: Bending the Arc of History Toward Justice for Generations of Children.