Pediatr Crit Care Me
-
Pediatr Crit Care Me · Sep 2007
Extracorporeal membrane oxygenation for refractory septic shock in children: one institution's experience.
To report our institutional experience of venoarterial extracorporeal membrane oxygenation (ECMO) in children with septic shock and circulatory collapse. ⋯ Extracorporeal membrane oxygenation can be safely used to resuscitate and support children with sepsis and refractory shock. Sepsis and multiorgan failure should not be considered a contraindication to ECMO. This study adds support to existing guidelines.
-
Pediatr Crit Care Me · Sep 2007
Randomized Controlled TrialProbiotic administration and the incidence of nosocomial infection in pediatric intensive care: a randomized placebo-controlled trial.
To evaluate the efficacy of probiotics in reducing the rates of nosocomial infection in pediatric intensive care. ⋯ The results of this preliminary investigation were unexpected but important in view of the increased use of probiotic preparations in medically fragile pediatric patients. In this randomized, placebo-controlled trial, L. rhamnosus strain GG was not shown to be effective in reducing the incidence of nosocomial infections. In fact, a statistically nonsignificant trend toward an increase in infection was seen (four vs. 11). Further studies with a larger patient population are needed to establish both safety and efficacy of probiotics in pediatric critical care.
-
Pediatr Crit Care Me · Sep 2007
Comparative Study Clinical TrialPharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: preliminary study.
To characterize the pharmacokinetics of dexmedetomidine and monitor any dexmedetomidine-related adverse events in postoperative pediatric patients requiring short-term mechanical ventilation, analgesia, and sedation in the pediatric intensive care unit (PICU). ⋯ Dexmedetomidine, administered as a continuous infusion, produces consistent, predictable concentrations in children and infants. Further evaluations of the safety, efficacy, and pharmacodynamics of dexmedetomidine are warranted.
-
Pediatr Crit Care Me · Sep 2007
Editorial CommentProbiotics in the critically ill: handle with care!