Pediatr Crit Care Me
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Pediatr Crit Care Me · Mar 2012
Importance of NOD2/CARD15 gene variants for susceptibility to and outcome of sepsis in Turkish children.
Severe sepsis remains a leading cause of morbidity and mortality in children. Given the link to pathogenesis, polymorphisms in genes involved in infection and inflammation may influence the outcomes in patients with sepsis and septic shock. The role of mutations within the innate immunity receptor NOD2/CARD15 has recently been demonstrated as a risk factor for bacteremia and mortality in adult patients with sepsis. The aim of this study was to evaluate the role of mutations of the NOD2/CARD15 gene in pediatric patients with sepsis. ⋯ The present article is the first report of clinical implications of NOD2/CARD15 gene variants in children with sepsis. Our findings suggest that common polymorphisms in the NOD2/CARD15 gene may play a major role in susceptibility to sepsis and the outcome of sepsis in children.
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Pediatr Crit Care Me · Mar 2012
Risk factors for cerebral edema in diabetic ketoacidosis in a developing country: role of fluid refractory shock.
To study the clinical profile and risk factors of cerebral edema in children with diabetic ketoacidosis with specific reference to fluid refractory shock. ⋯ Patients with fluid refractory shock and azotemia at admission had higher odds for development of cerebral edema. Initial blood glucose, effective osmolality, or decline in glucose and osmolality had no association with cerebral edema.
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Pediatr Crit Care Me · Mar 2012
Editorial CommentChest physiotherapy: how does it work (if it does)?.