Pediatr Crit Care Me
-
Pediatr Crit Care Me · Jun 2013
Review Meta AnalysisA systematic review and meta-analysis on the effect of steroids in pediatric shock.
To systematically review randomized controlled trials (RCTs) of steroids conducted in children with fluid and/or vasoactive medication-dependent shock and evaluate and report on the quality and clinical and methodological heterogeneity of included trials. ⋯ The literature on the use of steroids in pediatric shock is limited in amount and methodological quality and demonstrates conflicting results. The limited evidence on which current guidelines are based strongly supports the need for a well-designed, pragmatic randomized controlled trial on the use of steroids in pediatric shock to inform future guidelines.
-
Pediatr Crit Care Me · Jun 2013
ReviewSetup and maintenance of extracorporeal life support programs.
Setting up an extracorporeal life support program requires motivated experts, institutional commitment, and an interprofessional team of healthcare providers with dedicated time, space, and resources. This article provides guidance on the key steps involved in the process of developing a sustainable extracorporeal membrane oxygenation program, based on guidelines from the Extracorporeal Life Support Organization and from an international perspective.
-
Pediatr Crit Care Me · Jun 2013
Comparative StudyMobilization of endothelial progenitor cells from bone marrow is impaired in a piglet model of acute respiratory distress syndrome.
To characterize the endothelial progenitor cell mobilization in the models of moderate and severe lung injury, we hypothesized that there were differences in endothelial progenitor cell levels and mobilizing cytokines between moderate and severe lung injury. ⋯ There was a rapid release of endothelial progenitor cells from bone marrow into circulation in moderate acute lung injury, and endothelial progenitor cell mobilization was impaired in acute respiratory distress syndrome.