Pediatr Crit Care Me
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Pediatr Crit Care Me · Dec 2019
Prediction and Comparison of Fentanyl Infusion Pharmacokinetics in Obese and Nonobese Children.
To compare fentanyl infusion pharmacokinetic variables in obese children and nonobese children. ⋯ CLS may increase less than proportional to weight in obese children greater than 6-year-olds, while volume of distribution at steady state increases more than proportional to weight in all obese children compared with nonobese children. Weight-based dosing in obese children may cause an increase in steady-state concentration while prolonging the time to steady state. Exploring alternative dosing strategies for obese children is warranted.