Pediatr Crit Care Me
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Pediatr Crit Care Me · Aug 2022
Randomized Controlled Trial Multicenter StudyPhysical, Emotional/Behavioral, and Neurocognitive Developmental Outcomes From 2 to 4 Years After PICU Admission: A Secondary Analysis of the Early Versus Late Parenteral Nutrition Randomized Controlled Trial Cohort.
PICU patients face long-term developmental impairments, partially attributable to early parenteral nutrition (PN) versus late-PN. We investigated how this legacy and harm by early-PN evolve over time. ⋯ From 2- to 4-year post-PICU admission, developmental impairments remained prominent. Within that time-window, impaired growth in height, executive functioning and intelligence aggravated, and impaired memory and harm by early-PN only partially recovered. Impact on development into adulthood requires further investigation.
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Pediatr Crit Care Me · Aug 2022
Outcomes Associated With Timing of Neurologic Dysfunction Onset Relative to Pediatric Sepsis Recognition.
To compare outcomes associated with timing-early versus late-of any neurologic dysfunction during pediatric sepsis. ⋯ In this severe sepsis international cohort, the presence of neurologic dysfunction during sepsis is associated with worse outcomes at hospital discharge. The impact of early versus late onset of neurologic dysfunction in sepsis on outcome remains unknown, and further work is needed to better understand timing of neurologic dysfunction onset in pediatric sepsis.
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Pediatr Crit Care Me · Aug 2022
Comment Letter Meta AnalysisMissing Data in Systematic Reviews and Meta-Analysis.