British medical bulletin
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British medical bulletin · Sep 2021
Management of Gustilo-Anderson IIIB open tibial fractures in adults-a systematic review.
Open tibial fractures are the most common open long bone fracture, despite this, the management of these complex injuries still remains a topic of discussion amongst orthopaedic surgeons. ⋯ A national pragmatic trial into the management of open tibial fractures is required looking at fixation methods and soft tissue coverage, with at least a 2-year follow-up in order to ascertain the most appropriate management of these fractures and patient-related outcomes.
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British medical bulletin · Sep 2021
ReviewClinical trials in skeletal dysplasia: a paradigm for treating rare diseases.
Genetic skeletal dysplasia conditions (GSDs) account for 5% of all birth defects. Until recently, targeted treatments were only available for select few conditions; 1 however, opportunities arising from developments in molecular diagnostic technologies are now leading to unparalleled therapeutic advances. This review explores current GSD clinical trials, their challenges and the hopes for the future. ⋯ We horizon scan for future clinical trials.
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A major complication of total hip arthroplasty is dislocation. The hip joint capsule can be incised and repaired, or can be excised. ⋯ Appropriately powered randomized clinical trials should be conducted to better define the association between the chosen implants, approach and outcome.