Clin Lab
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Comparative Study
Comparison of the delta neutrophil index with procalcitonin and C-reactive protein in sepsis.
The purpose of this study was to compare the diagnostic performance of the delta neutrophil index (DNI) with procalcitonin and C-reactive protein (CRP) for the prediction of sepsis and its outcome. ⋯ The DNI can be obtained easily from automated hematological analysis and is cost effective. Furthermore, the DNI has a high diagnostic power for predicting sepsis and survival, similar to procalcitonin and better than CRP. The combination of DNI and procalcitonin may improve the ability to predict the severity of sepsis and survival.
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Beta-thalassemia causes a severe hemolytic anemia in patients necessitating frequent transfusions leading to iron overload and endocrine complications, especially diabetes mellitus. We tried to determine the change or effect on carbohydrate physiology and oxidation markers and the association of these markers in chronic transfusion-dependent beta-thalassemia major and beta-thalassemia/HbE (beta-TM) patients. ⋯ Progression of iron overload, oxidative stress and hyperinsulinemia were substantially and persistently higher in beta-TM patients. We observed a positive association between oxidative stress, iron overload and insulin resistance in these beta-TM patients.
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Adenosine deaminase (ADA) is a hydrolytic enzyme involved in the deamination of adenosine to inosine. ADA is involved in T-lymphocyte differentiation and development. This study was aimed to determine the diagnostic value of the adenosine deaminase (ADA) activity test for the diagnosis of HIV positive patients in the Kurdish population. ⋯ Serum ADA was significantly increased in HIV infected patients. Therefore, because of its low cost and simplicity to perform, ADA activity might be considered a useful diagnostic tool among the other markers in this disease.
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Recent evidence has demonstrated that environment and genetic factors play pivotal roles in diabetes and its related complications. The significant contributory role of cytokines in pathogenesis of type 2 diabetes is also well documented. This study was aimed to examine and compare both CXCL1 (GRO-alpha) and CXCL10 (IP-10) circulating levels in type 2 diabetic patients and healthy controls. ⋯ Elevated levels of CXCL1 and CXCL10 could possibly be used as a marker of inflammation and angiogenesis/angiostasis in type 2 diabetes.
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It has been thought that neurotrophins have metabotrophic effects and take part in the carbohydrate and lipid metabolism. The aim of the present study is to examine the levels of neurotrophins in type 2 diabetes mellitus (T2DM) and whether the levels are linked to the components of metabolic syndrome. ⋯ We thought that the changes in the serum neurotrophic factor levels were associated with metabolic syndrome components in T2DM.