J Rheumatol
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Randomized Controlled Trial Multicenter Study
A study to evaluate the safety, tolerability, and efficacy of brodalumab in subjects with rheumatoid arthritis and an inadequate response to methotrexate.
To evaluate the efficacy and safety of brodalumab, a human monoclonal antibody inhibitor of the interleukin 17 receptor, in subjects with rheumatoid arthritis (RA). ⋯ Our study failed to find evidence of meaningful clinical efficacy with brodalumab treatment in subjects with RA who had an inadequate response to MTX. These preliminary results do not support further evaluation of brodalumab as a treatment for RA. Clinicaltrials.gov number: NCT00950989.
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Multicenter Study Comparative Study
Risk of venous thromboembolism after total knee arthroplasty in patients with rheumatoid arthritis.
To compare the incidence of venous thromboembolism (VTE) following total knee arthroplasty (TKA) between patients with rheumatoid arthritis (RA) and those with osteoarthritis (OA). ⋯ Despite some differences in demographic data, patients with RA and OA have equivalent risks of VTE and bleeding following TKA.
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Randomized Controlled Trial
Effectiveness of total contact insoles in patients with plantar fasciitis.
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To develop a list of 5 tests or treatments used in rheumatology that have evidence indicating that they may be unnecessary and thus should be reevaluated by rheumatology healthcare providers and patients. ⋯ The list of 5 items has identified starting points to promote discussion about practices that should be questioned to assist rheumatology healthcare providers in delivering high-quality care.