The Medical journal of Australia
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Effectiveness of ototopical antibiotics for chronic suppurative otitis media in Aboriginal children: a community-based, multicentre, double-blind randomised controlled trial.
To compare the effectiveness of ototopical ciprofloxacin (0.3%; CIP) with framycetin (0.5%), gramicidin, dexamethasone (FGD) eardrops (5 drops twice daily for 9 days) together with povidone-iodine (0.5%) ear cleaning as treatments for chronic suppurative otitis media (CSOM) in Aboriginal children. ⋯ Twice-daily ear cleaning and topical ciprofloxacin is effective at community-level in achieving cure for CSOM. Healthcare providers to Aboriginal children with CSOM should be given special access to provide ototopical ciprofloxacin as first-line treatment.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Effectiveness of case management and post-acute services in older people after hospital discharge.
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Randomized Controlled Trial Clinical Trial
The demise of a planned randomised controlled trial in an urban Aboriginal medical service.
To fill a gap in knowledge about the effectiveness of brief intervention for hazardous alcohol use among Indigenous Australians, we attempted to implement a randomised controlled trial in an urban Aboriginal Medical Service (AMS) as a joint AMS-university partnership. Because of low numbers of potential participants being screened, the RCT was abandoned in favour of a two-part "demonstration project". ⋯ Clinic, patient, Aboriginal health worker, and GP factors, interacting with study design factors, all contributed to our inability to implement the trial as designed. The key points to emerge from the study are that alcohol misuse is a difficult issue to manage in an Indigenous primary health care setting; RCTs involving inevitably complex study protocols may not be acceptable or sufficiently adaptable to make them viable in busy, Indigenous primary health care settings; and "gold-standard" RCT-derived evidence for the effectiveness of many public health interventions in Indigenous primary health care settings may never be available, and decisions about appropriate interventions will often have to be based on qualitative assessment of appropriateness and evidence from other populations and other settings.
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Randomized Controlled Trial Comparative Study Clinical Trial
Mega-dose vitamin C in treatment of the common cold: a randomised controlled trial.
To determine the effect of large doses of vitamin C in the treatment of the common cold. ⋯ Doses of vitamin C in excess of 1 g daily taken shortly after onset of a cold did not reduce the duration or severity of cold symptoms in healthy adult volunteers when compared with a vitamin C dose less than the minimum recommended daily intake.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Will less liberal red-cell transfusion (with a lower haemoglobin threshold) still reduce rates of death and organ failure?