Deut Tierarztl Woch
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Deut Tierarztl Woch · Jun 2003
[Standing behavior in horses after inhalation anesthesia with isoflurane (Isoflo) and postanesthetic sedation with romifidine (Sedivet) or xylazine (Rompun)].
Isofluorane is a modern, only slightly depressive inhalation anaesthetic with excellent pharmacologic characteristics in use in equine medicine. In contrast to halothane, isofluorane is hardly broken down in the liver, but is eliminated by the lung. It low solubility in blood permits excellent control of anaesthesia. ⋯ Premedication with 0.08 mg/kg BW romifidine without postanaesthetic sedation (Group 3) could be carried out at mean duration of anaesthesia of 85 minutes with no negative effects observed during the recovery period. Premedication with xylazine without postanaesthetic sedation (Group 1) is not to be recommended, as the number of attemps to stand up was significantly higher and coordination was either weak or significantly poorer than in the other three groups. The results of this study show that post-anaesthetic sedation of horses with an alpha 2-adrenoceptor agonist can improve the recovery phase after inhalant anaesthesia with isofluorane in regard to the number of attempts to arise and the animals' physical coordination.
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Deut Tierarztl Woch · Nov 2002
The effect of Alkanna tinctoria Tausch on burn wound healing in rabbits.
Eighteen adult male New Zealand White rabbits were used in the treatment of partial thickness, severe and olive oil burns. Both right and left sides of the animals were burned to make partial thickness, severe and hot olive oil burn wounds. ⋯ It was topically applied twice a day by gently rubbing against the burn area. While complete healing of partial thickness and olive oil burn wounds occurred in 7 to 10, and 26 days, respectively, with well formed dermal-epidermal junctions in both groups, severely burned wounds appeared to be nonresponsive to A. tinctoria.
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Deut Tierarztl Woch · Mar 2002
[Development of animal welfare legislation for the European Community].
Animal welfare is of increasing importance for the European Community, which is reinforced by the Protocol to the EC Treaty on protection and welfare of animals. After the recent improvements to the legislation on the protection of pigs, the next priority for the Commission is the further development of the standards of animal transportation, particularly since a report of the Commission pointed out shortcomings in the enforcement of the existing rules in this area.
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Deut Tierarztl Woch · Mar 2002
[Possibilities and limits of the inspection of animal experiments and laboratory animal facilities].
Animal experiments according to section 7-9 of the German animal welfare act underlie governmental inspection. Generally this inspection is taken over by the veterinary offices of the cities and districts. During the inspection of animal experiments, which have to be licensed or announced according to section 8 or 8a respectively, the main focus should be the observance of the license presumptions and conditions, the knowledge of the experimenter and the necessity of recordings. ⋯ Without the participation and cooperation with the animal welfare officer the inspection office runs the risk not to recognize certain interrelations, but also to give way to wrong descriptions. It is very difficult especially during the inspection of institutions, where many research groups perform animal experiments to get and to keep an overview, without not noticing important details or focussing on certain details, while others are taken no notice of. The primary goal of the inspection of animal experiments should be: 1. to understand the research goal and the methods used 2. to ask with scientific background for the purpose of research and the experimental design 3. to judge the applied experimental methods in respect to animal welfare aspects 4. to improve the animal experimentation by discussion with the experimenter Does the inspection office succeed to be accepted as a competent partner by the experimenter as well as by the animal welfare officer, the inspection of animal experiments itself as well as the achievement of refinement for practical animal welfare is more easy and more effective than a simple bureaucratic control.
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Deut Tierarztl Woch · Oct 2001
Randomized Controlled Trial Comparative Study Clinical TrialClinical comparison of preanaesthetic intramuscular medetomidine and dexmedetomidine in domestic sheep.
Medetomidine and its active d-enantiomer, dexmedetomidine, are highly selective alpha-2 agonists with potent sedative, anaesthetic-sparing and analgesic effects. These properties make them an ideal pre-anaesthetic medication for noxious surgical procedures. However, sheep can develop adverse hypoxaemic effects after intravenous alpha-2 agonists. ⋯ The observed differences (heart rates, PaO2) between dexmedetomidine and medetomidine at the chosen dose relationship can be considered clinically not significant. At the chosen dose rates individual animals responded with a transient drop in blood oxygenation, therefore careful monitoring is required. In addition, in compromised sheep medetomidine and dexmedetomidine should be used carefully.