Nederlands tijdschrift voor geneeskunde
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Ned Tijdschr Geneeskd · Jan 2004
Multicenter Study[Modifiable determinants of delayed hospital admission following a cerebrovascular accident].
To identify the modifiable determinants of delayed hospital admission of stroke patients. ⋯ The modifiable determinants of delayed calling for professional help by stroke patients were the fact that they did not recognise the symptoms as a stroke, and the circumstance that they waited until the symptoms would disappear or become worse. This latter circumstance, referral by the family physician by telephone and transportation by ambulance, were modifiable determinants of delayed hospital admission.
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Ned Tijdschr Geneeskd · Jan 2000
Randomized Controlled Trial Multicenter Study Clinical Trial[Dutch research on the effectiveness of medical prescription of heroin; background, research design and preliminary results].
In the Netherlands the total number of heroin addicts amounts to approximately 25,000. Of these about 70% is in contact with the treatment system. The remaining 30% have not been seeking help, believes that no help is needed or has lost faith in a better future altogether. ⋯ During the treatment no medical complications have been observed and no serious public order or safety problems have occurred. Study participants have been very compliant both with the treatment regimen and the research requirements. The latter is indicated by the fact that 85% of all the two-monthly assessments have been completed.
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Ned Tijdschr Geneeskd · Aug 1998
Multicenter Study[The importance of steroid receptors for the prognosis and hormone treatment of breast cancer patients: a retrospective study in Southeastern Netherlands].
To assess the effect of oestrogen (ER) and progesterone (PgR) receptors on the prognosis of patients with operable breast cancer and the decision to treat these patients with adjuvant tamoxifen. ⋯ This study shows that ER and PgR receptors are significant prognostic factors for survival in breast cancer patients with involved axillary lymph nodes. The prognostic effect appeared to be restricted to the first four years after primary treatment. Selection of patients for endocrine treatment should be based on the steroid receptor status, considering the importance of the steroid receptors for predicting the response to endocrine treatment.
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Ned Tijdschr Geneeskd · Oct 1992
Randomized Controlled Trial Multicenter Study Clinical Trial[Prevention and treatment of respiratory distress syndrome in premature infants using intratracheally administered surfactants].
To study the effects of administration of surfactant immediately after birth (prophylactic) or after 6 hr (therapeutic) to 81 Dutch preterm infants from a multicentre trial. ⋯ Surfactant, given either prophylactically or therapeutically, results in clinical improvement of children with biochemically immature lungs. A prophylactic treatment, moreover, results in reduced incidence and severity of RDS, in a significant shortening of the time spent on the respirator and in reduced need of extra oxygen compared with therapeutic treatment. We recommend to give surfactant prophylactically or at the first signs of RDS.