Nederlands tijdschrift voor geneeskunde
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Ned Tijdschr Geneeskd · Jan 2014
[Irreversible electroporation: a new form of image-guided tumour ablation].
Irreversible electroporation (IRE) is a new, non-thermal image-guided tumour ablation technique. The repeated application of high-voltage electrical pulses causes pores to form in the cell membrane, so that cells lose their homeostatic properties, and die. The advantage of IRE over other local ablation techniques is that IRE selectively destroys cells, whilst the surrounding extracellular matrix structures remain intact. ⋯ Both in the Netherlands and worldwide, various clinical studies are being run on the safety and efficacy of IRE for centrally located hepatic and pancreatic tumours, which are unsuitable for the current local therapies (surgical resection, irradiation or thermal ablation) due to their anatomic location. Although the long-term results are as yet unknown, the future of IRE appears promising. IRE may prove a valuable tool to add in the multidisciplinary treatment of cancer.
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Hospital standardized mortality ratios (HSMR) are meant to compare mortality risks between hospitals. There is, however, much discussion about the value of the HSMR because incomplete adjustment for case mix is almost inevitable and because the data required to estimate HSMR are often unreliable. ⋯ The number of factors that can influence mortality risk in a hospital for these 50 diagnoses is enormous. There are many potential explanations for an increased (or decreased) HSMR, meaning that even if an increased HSMR really does point towards an increased mortality risk, this provides no real indication of the underlying cause.
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A rare disease usually concerns only a handful of patients, but all patients with a rare disease combined represent a significant health burden. Due to limited knowledge and the absence of treatment guidelines, patients with rare diseases usually experience delayed diagnosis and suboptimal treatment. Historically, rare diseases have never been considered a major health problem. ⋯ Two critical steps in optimising healthcare for rare diseases are developing multidisciplinary healthcare teams and stimulating patient empowerment. Optimal cooperation between patients, patient organisations, multidisciplinary healthcare teams and scientists is of great importance. In this respect, transition to adult healthcare requires special attention.
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Ebola is an exceptionally risky infection and safety measures are therefore unprecedentedly strict. However, despite stringent measures infection of health care providers by the Ebola virus cannot be excluded. ⋯ Before undertaking care for Ebola patients, 'fit for the job'screening is necessary. We should only expose our care givers if we know that they are physically and mentally up to the task.
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The treatment of chronic systolic heart failure has shown important improvements, but there are no evidence-based medical treatment options for patients with diastolic heart failure. A recent elaborate study, the TOPCAT trial, failed to show a beneficial effect of spironolactone on the primary composite endpoint of cardiovascular death or hospital admission for heart failure in patients with heart failure and preserved ejection fraction (HFpEF). ⋯ The difficulties in the study design and in interpreting the results of the TOPCAT study may contribute to this negative conclusion. However, a better understanding of the pathophysiology of HFpEF is needed to find strategies that improve the clinical outcome in patients with diastolic heart failure.