Ann Acad Med Singap
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Ann Acad Med Singap · Jul 2023
Effects of sex on clinical outcomes of hypertrophic cardiomyopathy in Singapore.
Despite the growing recognition that sex can affect the presentation and outcomes in hypertrophic cardiomyopathy (HCM), this relationship is understudied in Asians. Therefore, we aimed to explore sex differences in Asian patients with HCM. ⋯ Women diagnosed with HCM were older, had more comorbidities and were more likely to develop heart failure while men had a higher risk of all-cause mortality.
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Ann Acad Med Singap · Jul 2023
Clinical outcomes of hospitalised individuals with spin-induced exertional rhabdomyolysis.
Exertional rhabdomyolysis (ER) is caused by myocyte breakdown after strenuous physical activity. In recent years, the incidence of spin-induced ER (SER) has been increasing. We describe the clinical characteristics, management and outcomes of patients admitted for SER. ⋯ Inpatient management of SER includes laboratory investigations, analgesia and hydration. Risk of complications is low in SER patients. SER patients without risk factors for complications can be considered for hospital-at-home management with bed rest, aggressive hydration and early outpatient review.
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Ann Acad Med Singap · Jul 2023
Association between genetic polymorphisms in fibrinogen genes and bleeding risk in patients treated with direct oral anticoagulants.
This study aimed to investigate the association between polymorphisms in fibrinogen genes and bleeding risk in patients receiving direct oral anticoagulants (DOACs). ⋯ To our knowledge, this is the first study to investigate the effects of polymorphisms in fibrinogen genes on DOAC response. After validation, these results will be useful for personalised DOAC therapy.