Ann Acad Med Singap
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Ann Acad Med Singap · Aug 2024
Repetitive transcranial magnetic stimulation for major depression and obsessive-compulsive disorders in Singapore.
Repetitive transcranial magnetic stimulation (rTMS) is used for treatment-resistant major depressive disorder (MDD) and obsessive-compulsive disorder (OCD), but there are few studies on patient outcomes in Southeast Asia. In this study, we describe the clinical profile and outcome of patients with MDD and OCD treated with rTMS in Singapore. ⋯ Response and remission rates for MDD and OCD suggest patients have a good response to rTMS treatment. Dosing longer rTMS sessions after an acute course helps to maximise effectiveness. Further research to determine predictors of outcome and characterise clinical features of late responders to target treatment more effectively is recommended.
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Ann Acad Med Singap · Aug 2024
Long-term outcomes of subthalamic nucleus deep brain stimulation for Parkinson's disease in Singapore.
Subthalamic nucleus deep brain stimulation (STN-DBS) is a proven treatment modality for Parkinson's disease (PD), reducing dyskinesia and time spent in the "OFF" state. This study evaluates the long-term outcomes of STN-DBS in PD patients up to 10 years post-surgery in Singapore. ⋯ STN-DBS provides sustained relief from motor complications and reduced medication requirements in PD patients in Singapore. This study highlights STN-DBS as an effective treatment option, significantly enhancing the quality of life for those with PD.
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Ann Acad Med Singap · Aug 2024
Meta AnalysisQuality of life of family caregivers of children and young adults with Down syndrome: A systematic review and meta-analysis.
The aims of this systematic review and meta-analysis are to synthesise quality of life (QOL) of family caregivers of children and young adults with Down syndrome (DS) and determine factors affecting their QOL. ⋯ QOL of caregivers of children with DS was lower than population reference data. Understand-ing the factors that influence family caregivers' QOL is an essential step towards improving the QOL of caregivers and their children with DS.
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Ann Acad Med Singap · Aug 2024
Meta AnalysisQuality of life of children and young adults with Down syndrome from caregivers' perspective: A systematic review and meta-analysis.
Down syndrome (DS) negatively impacts the well-being of affected individuals. This study aimed to summarise the evidence on quality of life (QOL) of children and young adults with DS using quantitative measures from caregivers' perspective and identify factors that affected their QOL. ⋯ Children with DS have lower caregiver-reported QOL than TD children, especially in social functioning and school functioning subdomains.