Arch Iran Med
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Comparative Study
Global Incidence and Mortality Rate of COVID-19; Special Focus on Iran, Italy and China.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new coronavirus, was diagnosed in China in December 2019. Around the globe, a total of 71429 were infected up to February 17, 2020, with 98.9% of cases in China. On March 11, 2020, the World Health Organization (WHO) characterized the COVID-19 as 'pandemic'. Rapid positive worldwide incidence was the motivation behind this study to investigate the incidence and mortality globally. ⋯ The incidence of COVID-19 varied by regions; however, after March 11, it became 'pandemic'. It was observed that after about 6 days with an emergence of sharp increase in incidences, there would be a mutation in mortality rate. On the other hand, the importance of 'on-time' quarantine programs in controlling this virus was confirmed.
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A recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 1100000 (April 5, 2020) individuals worldwide and is spreading rapidly. The virus is reported to be derived from bats and the infection was first reported in China. ⋯ Guidelines from the Center for Disease Control and Prevention and the World Health Organization (WHO) should be followed for diagnostic and precautionary measures. Treatment of the infection is still not available; however, antivirals are under clinical trials.
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Multicenter Study
The First Inherited Retinal Disease Registry in Iran: Research Protocol and Results of a Pilot Study.
To describe the protocol for developing a national inherited retinal disease (IRD) registry in Iran and present its initial report. ⋯ Our study shows successful web-based software design and data collection as a proof of concept for the first IRD registry in Iran. Multicenter integration of the IRD registry in medical centers throughout the country is well underway as planned. These data will assist researchers to rapidly access information about the distribution and genetic patterns of this disease.
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Multicenter Study
Molecular Diagnosis of Hereditary Neuropathies by Whole Exome Sequencing and Expanding the Phenotype Spectrum.
Inherited peripheral neuropathies (IPNs) are a group of neuropathies affecting peripheral motor and sensory neurons. Charcot-Marie-Tooth (CMT) disease is the most common disease in this group. With recent advances in next-generation sequencing (NGS) technologies, more than 100 genes have been implicated for different types of CMT and other clinically and genetically inherited neuropathies. There are also a number of genes where neuropathy is a major feature of the disease such as spinocerebellar ataxia (SCA) and hereditary spastic paraplegia (HSP). We aimed to determine the genetic causes underlying IPNs in Iranian families. ⋯ Our results highlight the advantage of using WES for genetic diagnosis in highly heterogeneous diseases such as IPNs. Moreover, functional analysis is required for novel and uncertain variants.